New insights into the arrhythmogenic substrate of the long QT syndrome.

نویسنده

  • Arthur J Moss
چکیده

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[New insights into the long-QT syndrome].

Long QT Syndrome (LQTS) is an arrhythmogenic disease in which prolongation of cardiac repolarization alters electrical stability of the heart predisposing affected individuals to cardiac arrest. The first arrhythmic manifestations occur during adolescence and largely are triggered by increased sympathetic activity. Mutations in genes encoding ion channels or ion channels’ controlling proteins h...

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Background: Long QT syndrome (LQTS) is a disorder in which electrical cardiac ventricular repolarization is impaired. It results in an increased risk of an irregular heartbeat which can result in palpitations, fainting, drowning, or sudden death. Long QT Syndrome may present as tonic-clonic seizure or a seizure-like disorder. By taking a superficial electrocardiogram (ECG) and proper diagnosis,...

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Screening for, and management of, possible arrhythmogenic syndromes (channelopathies/ion channel diseases).

This survey assesses the current management strategies for individuals with electrocardiographic features, suggesting an arrhythmogenic syndrome [including long QT syndrome (LQTS), Brugada syndrome (BS), catecholaminergic polymorphic ventricular tachycardia (CPVT) or short QT syndrome] or family members of patients with a known arrhythmogenic syndrome, in 44 large European centres. The principa...

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عنوان ژورنال:
  • Circulation

دوره 130 22  شماره 

صفحات  -

تاریخ انتشار 2014